https://hdl.handle.net/20.500.12177/99 Sat, 18 Apr 2026 13:42:15 GMT 2026-04-18T13:42:15Z https://hdl.handle.net/20.500.12177/13152 Title: Chemical Study of the Essential Oils of Mischogyne elliotiana (Engl. & Diels) (Annonaceae) and Daniellia ogea (Harms) Rolfe (Fabaceae), Obtained by Hydrodistillation and Steam Distillation Authors: KOUAME, Bosson Antoine; N'DRI, Koffi Alfred; KONAN, N'dri Séraphin; MAMYRBÉKOVA-BEKRO, Janat Akhanovna; BEKRO, Yves-Alain Abstract: Extracted from Mischogyne elliotiana and Daniellia ogea by hydrodistillation (HD) and steam distillation (SD) have been determined. EO yields are (HD: 0.012% - SD: 0.11%) for Mischogyne elliotiana and (HD: 0.06% - SD: 0.05%) for Daniellia ogea. Essential oils have been analyzed by Gas Chromatography-Mass Spectrometry. Essential oils obtained by hydrodistillation revealed more compounds than those obtained by steam distillation: Mischogyne elliotiana (HD: 32 compounds - SD: 24 compounds), Daniellia ogea (HD: 40 compounds - SD: 38 compounds). The essential oils of Mischogyne elliotiana consist mainly of sesquiterpenes. The hydrocarbon sesquiterpene content is: (HD: 87.18% - SD: 94.27%). Oxygenated sesquiterpenes: (HD: 9.98% - SD: 3.76%). Daniellia ogea EO is made up of oxygenated sesquiterpenes (HD: 34.14% - EV: 32.64%), diterpenes (HD: 2.07% - SD: 0.51%) and other compounds (HD: 7.15% - SD: 11.47%). Hydrocarbon monoterpenes (0.15%) are present only in the oil obtained by hydrodistillation. The main compounds in Mischogyne elliotiana EO obtained by hydrodistillation are α-gurjunene (58.14%) and β-guaiene (8.26%), while those obtained by steam distillation are α-gurjunene (50.60%) and β-guaiene (8.30%). In Daniellia ogea essential oils, the main compounds obtained by hydrodistillation are caryophyllene oxide (19.91%), β-caryophyllene (17.83%) and β-farnesene (15.56%), while those obtained by steam distillation are also caryophyllene oxide (18.92%) and β- caryophyllene (15.87%). The study on Mischogyne elliotiana essential oil is described for the first time. Wed, 04 Mar 2026 00:00:00 GMT https://hdl.handle.net/20.500.12177/13152 2026-03-04T00:00:00Z https://hdl.handle.net/20.500.12177/12973 Title: Monomeric and oligomeric flavanols are agonists of membrane androgen receptors Authors: Nifli, Artemissia-Phoebe; Kouamé, Bosson Antoine; Papadopoulou, Natalia; Kogia, Christina; Kampa, Marilena; Castagnino, Chantal; Stournaras, Christos; Vercauteren, Joseph; Castanas, Elias Abstract: The present work reports a new mode of action of the naturally occurring flavanols catechin and epicatechin and their dimers B2 and B5, in the breast cancer T47D cell line, namely, their interaction with membrane androgen receptors. We show that monomeric and dimeric flavanols are complete (B2) or partial displacers of radiolabeled testosterone bound on T47D membranes, with affinities ranging from 1.7 (B5) to 82.2 nM (B2). In addition, they trigger the phosphorylation of the same signaling molecules (FAK, PI3K) as testosterone-BSA, minutes after binding to membrane receptors, leading to actin cytoskeleton polymerization and redistribution, with formation of filopodia and lamellipodia. The PI3K inhibitor wortmannin reverts the effect of polyphenols and testosterone-BSA, providing additional evidence about activation of a similar signaling cascade. Incubation of T47D cells for more than 2 h with polyphenols or testosterone-BSA induces apoptosis, which follows the same time-dependent pattern. We conclude that flavanols (monomers or dimers) are agonists of membrane androgen receptors and could be used as testosterone – protein conjugates for the management of tumors, in which, application of testosterone-BSA induces regression, providing additional data about the mechanism of their antiproliferative action. Tue, 21 Jun 2005 00:00:00 GMT https://hdl.handle.net/20.500.12177/12973 2005-06-21T00:00:00Z https://hdl.handle.net/20.500.12177/12972 Title: COMPOSITION CHIMIQUE PAR GC/SM DES HUILES ESSENTIELLES EXTRAITES DES FEUILLES DE MIKANIA CORDATA (BURM. F.) B. L. ROBINSON ET DE SYNEDRELLA NODIFLORA (L.) GAERTN. Authors: Konan, N'dri Séraphin; Kouamé, Bosson Antoine; Mamyrbékova-Békro, Janat Akhanovna; Konan, Koffi Marcel; Békro, Yves-Alain Abstract: Dans le but de contribuer à la valorisation la biodiversité floristique de Côte d’Ivoire en vue d’identifier de nouvelles molécules potentiellement intéressantes tant sur le plan biologique que thérapeutique, nous avons étudié la composition chimique des huiles essentielles (HE) issues des parties aériennes de Mikania cordata et de Synedrella nodiflora au moyen de la chromatographie en phase gazeuse couplée avec la spectrométrie de masse (GC/SM). Plus de 98,46% des composés ont été identifiés dans l’HE de chaque organe. L’HE de Synedrella nodiflora est constituée principalement de sesquiterpènes (90,31%), monoterpènes (6,93%) et d’autres composés (1,86%). Les composés majoritaires sont le β-caryophyllène (19,52%), le germacrène D (17,63%), le caryophyllène oxyde (10,50%) et le β-élémène (9,80%). Quant à celle de Mikania cordata, elle est composée de 44,20% de sesquiterpènes hydrocarbonés, 42,20% de monoterpènes, 9,20% de sesquiterpènes et de 2,98% d’autres composés. Ses principaux composés sont l’α-pinène (19,56%), le β-pinène (12,42%), le germacrène D (9,10%) et le β-caryophyllène (8,45%). Tue, 04 Oct 2011 00:00:00 GMT https://hdl.handle.net/20.500.12177/12972 2011-10-04T00:00:00Z https://hdl.handle.net/20.500.12177/12971 Title: Chemical characterisation of essential oils of leaves of two Solanaceae: Solanum rugosum and Solanum erianthum from Côte d’Ivoire Authors: Kouao, Toffe Alexis; Kouamé, Bosson Antoine; Ouattara, Zana Adaman; Mamyrbekova-Bekro, Janat Akhanovna; Bighelli, Ange; Tomi, Felix; Békro, Yves-Alain Abstract: This study made it possible to characterise by GC (in combination with retention indices), GC-MS and 13C NMR, the chemical com- position of the essential oils from Solanum rugosum and Solanum erianthum, two Solanaceae of the Ivorian flora. The two essential oils were characterised by a very high proportion of sesquiter- penes. Specifically, the essential oil of S. rugosum was dominated by (E)-b-caryophyllene (33.7%), b-elemol (19.8%) and germacrene D (14.4%), while that of S. erianthum was mainly composed of a-humulene (38.6%), b-elemol (17.8%) and (E)-b-caryophyllene (16.7%). The chemical composition of Solanum rugosum is described here for the first time. Thu, 03 Oct 2019 00:00:00 GMT https://hdl.handle.net/20.500.12177/12971 2019-10-03T00:00:00Z